Generic Daklinza (Daclatasvir )
Daklinza
Daklinza (daclatasvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body. Daklinza is used to treat genotype 1 and genotype 3 chronic hepatitis C in adults with or without cirrhosis.
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Product Description
Foster City, California: Gilead Sciences; Daklinza daclatasvir Profile. Please click here for the Daklinza full prescribing information. We will not rent Daklinaa email to anyone. Regenerative Medicine: Steps to Accelerate Development. The safety and effectiveness of daclatasvir for people with HIV and HCV co-infection has not yet been determined, but this is now being tested. What are the side-effects of daclatasvir? Daklinza forms the lynchpin of Bristol-Myers Squibb's hepatitis C aspirations and its Sovaldi combination continues to be investigated Dakliinza a Dakpinza for patients with high unmet needs in hepatitis C. These factors may be overcome by prolonging treatment or by adding another direct-acting antiviral or ribavirin. Does daclatasvir interact with other drugs? How effective is daclatasvir? Coadministration of daclatasvir, sofosbuvir and amiodarone is therefore not advised. Contraindications Daclatasvir is contraindicated when coadministered with drugs that are strong inducers of CYP3A, including phenytoin, carbamazepine, rifampin, and St. Liver Enzymes Learn about the importance of testing liver enzyme levels and causes of abnormal levels. One of its major benefits is that it does not need to be used with interferon alpha therapy, the current standard course of treatment that has possible side effects including depression, insomnia and flu-like symptoms. How is daclatasvir taken? Daclatasvir is a CYP3A and p-glycoprotein substrate, therefore, drugs that are strong inducers or inhibitors of these enzyme will interfere with daclatasvir levels in the body. The expanded label includes data in three additional challenging-to-treat patient populations: chronic hepatitis C virus HCV patients with HIV-1 coinfection, advanced cirrhosis, or post-liver transplant recurrence of HCV. By week6, approximately half of the patients received mg per day or less of ribavirin. As we continue to strive for more preventive DDaklinza options for HCV, we are actively pursuing means to eradicate the spread and incidence of this chronic disease and associated complications. Jan 21, Each day, HCV makes billions of copies of itself. Genotype 1 or Genotype 3 without cirrhosis. Daklinza can be used in mild, moderate, or severe hepatic impairment without dose adjustment. Sovaldi—which is used with Daklinza—should not be used with a medication called amiodarone because it can cause life-threatening heart problems. Resistance to certain hepatitis C drugs can disappear within months. Give a list of all your medicines to any healthcare provider who treats you. What are the side-effects of daclatasvir? Customer Relations Daclatasvir plus weekly pegylated interferon Dakllnza and ribavirin pills for 24 weeks is another option for people with genotype 4. Daclatasvir should be combined with other medications, which may include other direct-acting antivirals that work differently — sofosbuvir Sovaldi or the HCV protease inhibitor asunaprevir Sunvepra — or pegylated interferon and ribavirin. While taking Daklinza with ribavirin, use at least 2 effective forms of birth control to prevent pregnancy, whether you are a man or a woman. Submit a Medical Inquiry Submit your question to our team of medical professionals. Daclatasvir can be used by people with all stages of compensated liver disease including cirrhosis. Daclatasvir is now being tested for people with chronic hepatitis C who are awaiting or have received liver transplants. How can I get assistance paying for Daklinza? Genotype 1 is the most common type in Europe and considered the hardest to treat. However, administration after a low-fat, low-calorie meal did not result in a significant decrease in absorption. HCV is predisposed to the development of resistance due to its highly variable genome. Indications Daclatasvir is indicated for use, with sofosbuvir, with or without ribavirin for the treatment of patients with chronic HCV genotype 1 or 3. A state-by-state and worldwide reference listing physicians who treat HCV, including an email link to submit your physician for inclusion. Administration of daclatasvir tablets in HCV-infected patients resulted in approximately dose-proportional increases in peak concentration C maxarea under the curve AUCand minimum concentration up to 60 mg once daily. Cirrhosis Many discussions and analyses of cirrhosis, including causes, complications, pathology, symptoms, and much more. Hepatitis C Symptoms You'll find links to a comprehensive symptoms list, as well as various studies and discussions about Hepatitis C symptoms. It is not known whether Daklinza causes harm to unborn babies. Contact Us Confidential helpline Email enquiries helpline hepctrust. How is daclatasvir taken? Merck plans to discontinue boceprevir for hepatitis C by December Adverse Events or Product Quality Complaints Drug Summary Daclatasvir plus sofosbuvir, with or without ribavirin, is an all-oral option for the treatment of genotype 1 or 3 chronic HCV across a variety of patient populations.

Daklinza - assured

Combining colonies that have severe targets of action with synergistic orthomolecular gains will possibly alter the category of recalcitrant to antivirals. Talk with your dose about safe ways to review HCV transmission during sex. Jul 6, How it works Daclatasvir, the united advocacy in Daklinza, scars the action of a jelly in the hepatitis C virus treated NS5A which is very for the virus to consciously. Dermatologists with liver system do not enough as well as those with mild or bare liver problem. Overview of cost, automobile, and cost-effectiveness considerations for advice C lock obsessions. Read the condition guide or asking instructions provided with each day in your adrenal therapy. See also: Daklinza side effects in more detail. In Specifics BMS announced that it would offer the drug for sale at higher prices in different things, cleaning on the level of cervical development, and that it would think the drug to deaths manufacturers for sale in the sensory world. Daclatasvir plus sofosbuvir for 24 weeks was also tested in a smaller number of previously untreated people with HCV genotype 2 or 3. You'll also receive our Dwklinza and special offers to support liver health. These include some antibiotics, TB medications, anti-seizure drugs and herbal products containing St John's wort. But resistance to certain drugs, including Daklinza, can last for years—and might limit re-treatment options. Daclatasvir plus sofosbuvir for 24 weeks was also tested in a smaller number of previously untreated people with Dajlinza genotype 2 Daklnza 3. Retrieved 6 December Administration of daclatasvir tablets in HCV-infected patients resulted in approximately dose-proportional increases in peak concentration C maxarea under the curve AUCand minimum concentration up to 60 mg once daily. Genotype 3 with compensated cirrhosis Child-Pugh A. A lower or higher dose of Daklinza may be needed when it is used with certain antiretrovirals. The Daklinza plus sofosbuvir regimen is already available for the treatment of chronic HCV genotype 3, and is currently the only week, once-daily all-oral treatment option for these patients. Listing a study does not mean it has been evaluated by the U. HCV is predisposed to the development of resistance due to its highly variable genome. Although data in humans are lacking, maternal and embryo-fetal toxicities were observed in animal studies. These factors may be overcome by prolonging treatment or by adding another direct-acting antiviral or ribavirin. Study Description. Privacy Policy. Certain mutations make Daklinza less effective, including one called Y93H. Daklinza is also compatible with many immunosuppressive regimens, with no treatment-limiting drug-drug interactions.

Common use
The active ingredient present in is daclatasvir – 60 mg.
Daklinza is a drug for the treatment of hepatitis C (HCV). Daclatasvir inhibits the HCV nonstructural protein NS5A. Recent research suggests that it targets two steps of the viral replication process, enabling rapid decline of HCV RNA. Daklinza is indicated for use with sofosbuvir, with or without ribavirin, for the treatment of patients with chronic hepatitis C virus (HCV) genotype 1 or genotype 3 infections.
It is advised to avoid pregnancy during combination treatment with Daklinza and sofosbuvir with ribavirin for 6 months after completion of treatment.

Dosage and direction
The recommended dosage of Daklinza is 60 mg, taken orally, once daily, with or without food.
Recommended Treatment Regimen and Duration for Daklinza
Genotype 1:
Without cirrhosis - Daklinza + sofosbuvir for 12 weeks
Compensated (Child-Pugh A) cirrhosis - Daklinza + sofosbuvir for 12 weeks
Decompensated (Child-Pugh B or C) cirrhosis - Daklinza + sofosbuvir + ribavirin for 12 weeks
Post-transplant - Daklinza + sofosbuvir + ribavirin for 12 weeks
Genotype 3:
Without cirrhosis - Daklinza + sofosbuvir for 12 weeks
Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis - Daklinza + sofosbuvir + ribavirin for 12 weeks
Post-transplant - Daklinza + sofosbuvir + ribavirin for 12 weeks
For specific dosage recommendations for sofosbuvir, refer to the prescribing information.

Precautions
The concomitant use of Daklinza and other drugs may result in known or potentially significant drug interactions, some of which may lead to loss of therapeutic effect of Daklinza and possible development of resistance, dosage adjustments of concomitant medications or Daklinza, possible clinically significant adverse reactions from greater exposures of concomitant drugs or Daklinza.
Postmarketing cases of symptomatic bradycardia and cases requiring pacemaker intervention have been reported when amiodarone is coadministered with sofosbuvir in combination with another HCV direct-acting antiviral, including Daklinza. A fatal cardiac arrest was reported in a patient receiving a sofosbuvir-containing regimen (ledipasvir/sofosbuvir). Bradycardia generally resolved after discontinuation of HCV treatment. The mechanism for this bradycardia effect is unknown.
For patients taking amiodarone who have no alternative treatment options and who will be coadministered Daklinza and sofosbuvir need cardiac monitoring for the first 48 hours of coadministration, after which outpatient or self-monitoring of the heart rate should occur on a daily basis through at least the first 2 weeks of treatment.

Contraindications
Drugs that are Contraindicated with Daklinza:
Anticonvulsants - phenytoin, carbamazepine
Antimycobacterial agents - rifampin
Herbal products - St. John’s wort (Hypericum perforatum)

Possible side effect
Most common side effects occurred during the trials in combination with sofosbuvir (with or without ribavirin), with peginterferon alfa/ribavirin, with asunaprevir, or with asunaprevir/peginterferon alfa/ribavirin are such: fatigue, headache, pruritus, insomnia, influenza-like illness, dry skin, nausea, decreased appetite, alopecia, rash, asthenia, irritability, myalgia, anemia, pyrexia, cough, dyspnea, neutropenia, diarrhea, arthralgia, neutropenia, anemia, thrombocytopenia, and lymphopenia.
If you take Daklinza with sofosbuvir and you also take a heart rhythm medicine called amiodarone: This combination of medicines can cause dangerous side effects on your heart.

Drug interaction
Potential for Other Drugs to Affect Daklinza (clinically relevant increase in concentration):
HIV antiviral agents - Atazanavir with ritonavirb; Indinavir; Nelfinavir; Saquinavir
Other antiretrovirals - Cobicistat-containing antiretroviral regimens e.g. atazanavir/cobicistat,
elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate
Anticoagulants - Dabigatran etexilate mesylate
Strong inhibitors of CYP3A (eg, clarithromycin, itraconazole, ketoconazole, ritonavir) may increase the plasma levels of daclatasvir.
Potential for Daklinza to Affect Other Drugs (clinically relevant decrease in concentration):
Non-nucleoside reverse transcriptase inhibitors (NNRTI) - Efavirenzb; Etravirine; Nevirapine
Moderate CYP3A inducers (see also HIV antiviral agents) - Examples: bosentan, dexamethasone, modafinil,
nafcillin, rifapentine.
Daclatasvir is an inhibitor of P-glycoprotein transporter (P-gp), organic anion transporting polypeptide (OATP) 1B1 and 1B3, and breast cancer resistance protein (BCRP). Administration of Daklinza may increase systemic exposure to medicinal products that are substrates of P-gp, OATP 1B1 or 1B3, or BCRP, which could increase or prolong their therapeutic effect or adverse reactions.

Missed dose
Take Daklinza every day at the regularly scheduled time with or without food. It is important not to miss or skip doses and to take Daklinza for the duration that is recommended by the physician. For instructions for missed doses of other agents in the regimen, refer to the respective prescribing information.

Overdose
There is no known antidote for overdose of Daklinza. Treatment of overdose with Daklinza should consist of general supportive measures, including monitoring of vital signs and observation of the patient’s clinical status. Because daclatasvir is highly protein bound (>99%), dialysis is unlikely to significantly reduce plasma concentrations of the drug.

Storage
Store Daklinza tablets at 25°C (77°F), with excursions permitted between 15°C and 30°C (59°F and 86°F). Store away from moisture and heat. Keep all drugs out of the reach children and pets.

Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Antibiotics

Antibiotics is one of most prescribed group of medications. Antibiotics are antibacterial (antimicrobial agents) that kills bacteria(bactericidal) or stop the growth of the bacteria(bacteriostatic action).

Antibiotics are used to treat bacterial infections and are not indicated for the viral infections. Currently there is a big variety of antibiotics available. All the antibiotics are divided into two main groups according to the action mechanism:

  • Antibiotics with bactericidal action(penicillins, cephalosporins, aminoglycoside)
  • Antibacterial with bacteriostatic action(macrolides, tetracyclines)

Penicillins and cephalospororins are the most prescribed group of antibiotics. They belong to half-synthetic beta lactam antibiotics. These antibiotics work by inhibiting the enzymes responsible for the production of peptidoglycan. Peptidoglycan is a biopolimer that is a main structural component of the bacterial cell wall. The blockage of peptidoglycan synthesis leads to the lysis of the microorganisms.

Another group of preparations are aminoglycosides. However, these antibiotics are prescribed in rare cases. The most of aminoglycosides possesses nephrotoxicity, ototoxicity and cab cause neuromuscular blockage. Bactericidal action of aminoglycosides is related to the interfering with the synthesis of proteins on the ribisomes in the microbial cells. When aminoglycosides are used with penicillins and cephalosporins the sinergism against gram-positive and gram-negative microorganisms is observed.

Among all bacteriostatic antibiotics macrolides and tetracyclines are the most indicated groups. Therapeutic effect of macrolides is associated with inhibiting the synthesis of proteins on the ribosomes in the microbial cell. As usual macrolides exert bacteriostatic action, however in high amounts are able to exert bactericidal action on some microorganisms. Besides antibacterial action, some macrolides possesses immunomodulatory and anti-inflammatory action.

Another group of bacteriostatic antibiotics are used less frequently as many microorganisms became resistant to the this type of antibiotics. Bacteriostatic effect of the tetracyclines is associated with inhibiting the synthesis of proteins. Tetracycline are indicated in clamydia infections, rickettsial disease, some zoonosis, severe acne.

Antibiotics are indicated and used only in the cases of the bacteria is sensitive to the antibiotics. There some specific tests like antibiogram that will help to determine the right antibiotic and corresponding dose.